Liver damage can lead to serious consequences, including death. These lesions can be caused by drugs, alcohol abuse, a physical shock such as a road accident, some viral infections, and other medical conditions. The hepatoprotective effect of black garlic has been the subject of several studies that have attributed its benefits to its antioxidant and anti-inflammatory properties.
To measure the antioxidant effect of black garlic, a group of Taiwanese biotechnology researchers measured the activity of several antioxidant enzymes in the liver. Eighty mice were allocated to eight experimental groups. Each of these groups, except one, received a treatment to induce hepatic injury. Black garlic extract was administered to the mice for seven consecutive days. At the end of the week, blood and liver samples were taken.
In response to black garlic administration, the analyzes revealed significant variations in the activity of four antioxidant enzymes of the liver, superoxide dismutase, catalase, glutathione peroxidase, and glutathione reductase. The increase in the activity of these enzymes could contribute to reduce the liver lesions induced by free radicals. The results obtained with black garlic were comparable to those measured with silymarin, a compound widely used in the prevention and treatment of liver diseases.
Part of the beneficial effects of black garlic could be attributable toits ability to increase the activity of certain antioxidant enzymes of the liver. In mice, the hepatoprotective effect was detectable after as little as seven days of treatment.
Tsai JC, Chen YA, Wu JT, Cheng KC, Lai PS, Liu KF, Lin YK, Huang YT, Hsieh CW. Extracts from Fermented Black Garlic Exhibit a Hepatoprotective Effect on Acute Hepatic Injury. Molecules. 2019 Mar 20;24(6). pii: E1112. doi: 10.3390/molecules24061112