The effect of black garlic on vascular disorders induced by a poor diet

Diet can be an important cause of many metabolic disorders, such as cholesterol, diabetes, hypertension and obesity. A Spanish research team investigated the effect of black garlic in rats fed a diet high in fat and sugar for twelve weeks to induce metabolic and vascular disorders. By the eighth week, half of them received black garlic extract every day for the last four weeks.

At the end of these twelve weeks, several parameters were improved in the rats that have received black garlic. Low density lipoprotein cholesterol (LDL-C) and triglycerides, two factors that can form plaques on the blood vessels, have decreased significantly while high density lipoprotein cholesterol (HDL-C), which removes excess cholesterol, increased following black garlic administration. Positive results were also measured in the insulin resistance test, calculated with fasting glucose and fasting insulin. While insulin resistance almost doubled due to the high-fat, high-sugar diet, black garlic allowed insulin sensitivity to decrease at almost the same level than rats fed with regular diet. Measurements obtained for vascular capacity also demonstrated results in favor of black garlic, reversing the stifness of the aorta that had been induced by the high-fat, high-sugar diet.

In this model of animal obesity induced by a diet rich in fat and sugar, the authors were able to observe favorable metabolic and vascular effects following the administration of black garlic.

Amor S, González-Hedström D, Martín-Carro B, Inarejos-García AM, Almodóvar P, Prodanov M, García-Villalón AL, Granado M. Beneficial Effects of an Aged Black Garlic Extract in the Metabolic and Vascular Alterations Induced by a High Fat/Sucrose Diet in Male Rats. Nutrients. 2019 Jan 12;11(1). pii: E153. doi:10.3390/nu11010153